#342: Unlocking The Secret Code To Fasting: The Biohack for Hunger, Longevity & Energy (How Scientists Are Hacking Your CELLS) | Chris Rhodes
Welcome back to the Longevity Podcast! I’m so excited for today’s episode, where I sit down with Chris Rhodes—nutritional biochemist, fasting researcher, and CEO of Mimio Health—to dive deep into one of the most fascinating emerging topics in longevity science: fasting mimetics. If you’ve ever wanted to get the regenerative, anti-inflammatory, and health-boosting effects of fasting, but struggled to actually fast for 36 hours or more (trust me, I get it!), this conversation is for you.
Chris breaks down the research behind four key metabolites our bodies naturally produce during long fasts. He’s harnessed them into a supplement designed to trigger those same longevity and repair pathways—even when you’re eating. We talk about what’s actually happening in the body when you fast, how different fasting strategies compare, common misconceptions (like “does the brain really prefer ketones?”), and why fasting is more than just a tool for weight loss—it’s about cellular cleanup, repair, and long-term resilience.
We also chat about how these fasting mimetics could change the game for people who can’t or shouldn’t fast—think athletes, older adults, or anyone for whom fasting could be risky—as well as some surprising benefits like better appetite control. Plus, you’ll hear about what’s next in the world of biohacking supplements (hint: “exercise in a pill” might be closer than you think). If you’re curious about the future of personalized wellness, anti-aging, or just want to make the benefits of fasting more accessible in your everyday life, you’re going to love this episode!
Listeners of this podcast can visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order.
Learn more from Chris Rhodes below:
Website: http://mimiohealth.com/nat
Instagram: https://www.instagram.com/mimiohealth/
YouTube: https://www.youtube.com/@mimiohealth
Facebook: https://www.facebook.com/mimiohealth
What We Discuss:
Meet Chris Rhodes and his biomimetic research journey ... 00:05:18
Unlocking fasting benefits without prolonged fasting ... 00:09:10
Supplements vs. pharmaceuticals for longevity ... 00:10:53
Fasting protocols, timing, and metabolic switching ... 00:15:23
Risks of fasting, evolutionary adaptation, and muscle/bone loss ... 00:18:34
Ketones, brain energy, and cognitive adaptation ... 00:22:48
How fasting activates longevity and repair pathways ... 00:26:23
Key cellular pathways: AMPK, mTOR, NAD, sirtuins ... 00:28:04
Mimio research: discovering and testing fasting metabolites ... 00:33:35
The four main fasting mimetic molecules explained ... 00:42:04
Practical benefits: who should use fasting mimetics & safety ... 00:59:00
Mimio in use: hunger control, GLP-1 support, and older adults ... 01:03:37
Our Amazing Sponsors:
Qualia NAD+ - This vital molecule powers cellular energy, supports DNA health, aids detox, and helps keep your body remain youthful. Visit qualialife.com/nathalie to try Qualia NAD+, backed by a 100-day money-back guarantee, and use promo code NATHALIE for 15% off!
Profound Health OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. Check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order.
Bio-Shield by Young Goose - A broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light. VisitYoungGoose.com—use code NAT10 to get started, or 5NAT if you’re an existing customer.
More from Nat: